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Whole blood cells suitable for use in complement titration, adsorption procedures, testing for agglutinins/HA assays, and the preparation of stroma as particulate reagents.
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A glycine-conjugated form of chenodeoxycholic acid; reduces formation of cholic acid in primary human hepatocytes at 100 µM; reduces the number LC3 puncta and is cytotoxic to L-02 hepatocytes at 50, 75, and 100 µM; induces apoptosis in isolated rat hepatocytes at 50 µM; fecal levels are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet
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An intermediate in aromatic amino acid metabolism; inhibits LPS-induced IL-6 and NO production in RAW 264.7 macrophages (IC50s = 2 and 0.5 mM, respectively); decreases serum starvation-induced mitochondrial superoxide production in EA.hy926 endothelial cells in vitro; increases survival in a rat model of hemorrhagic shock; serum and urinary levels are increased in patients with alkaptonuria
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A phenol with diverse biological activities; scavenges DPPH and hydroxyl radicals in cell-free assays (IC50s = 9.4 and 191 µM, respectively); reverses abscisic acid-induced inhibition of hypocotyl growth in A. caudatus seedlings from 1-100 µM; inhibits morpholine- and sodium nitrite-induced adenocarcinoma formation in mice at 21.8 g/kg; inhibits passive cutaneous anaphylaxis in mice at 50 mg/kg
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A naturally occurring fatty acid methyl ester; has been found in the cuticular wax of P. abies needles; has been found in sediment samples from the Harney River in Florida and Lake Kivu in the EAst African rift valley
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A partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay); induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle; completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs (5 mg/kg); reverses the antitussive effect of baclofen in cats (3 mg/kg)
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